CMBD Journal Club

CENTER FOR METABOLIC BONE DISEASE
JOURNAL CLUB: BONE AND CARTILAGE:
BIOLOGY AND DISEASE

The CMBD Journal Club meets the first Thursday of every month, 4:30-5:30 p.m. in the West Pavilion Conference Center. Discussions include one basic and one clinical article.

2008
01-03-08	Basic Research Article: Heather M. McDonald, PhD. Vitovski S, Phillips JS, Sayers J, Croucher PI. Investigating the Interaction between Osteoprotegerin and Receptor Activator of NF-?? or Tumor Necrosis Factor-related Apoptosis-inducing Ligand. J Biol Chem 2007;282:31601-31609. Clinical Research Article: Kenneth G. Saag, MD, MSc Mackey DC, Lui LY, Cawthon PM, Bauer DC, Nevitt MC, Cauley JA, et al. High-Trauma Fractures and Low Bone Mineral Density in Older Women and Men. JAMA 2007;298:2381-2388.
02-07-08	Basic Research Article: Joseph P. Ritchie Clinical Research Article: Elizabeth L. Perkins, MD. Articles: To be determined
03-20-08	Basic Research Article:Jason W. Ashley Clinical Research Article: Christina V. Oleson, MD Articles: To be determined
04-03-08	Basic Research Article:Majd Zayzafoon, MD, PhD. Clinical Research Article: Bita Shakoory, MD Articles: To be determined
05-01-08	Basic Research Article: Ryan Riddle, PhD. Clinical Research Article: Shawn R. Gilbert, MD Articles: To be determined
06-19-08	Basic Research Article:Amjad Javed, PhD. Clinical Research Article: Elizabeth M. Kitchin, BS, MS, RD Articles: To be determined
2007
01/04/07	Basic Research Article: April Adams Szafran, BA Kawane K, Ohtani M, Miwa K, Kizawa T, et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 2006;443:998-1002. Clinical Research Article: Maria I. Danila, MD, MS De Nijs RNJ, Jacobs JWG, Lems WF, Laan RFJ, et al. Alendronate or Alfacalcidol in Glucocorticoid-Induced Osteoporosis. N Engl J Med 2006;355:675-684.
02/01/07	Basic Research Article: Anthony J. Siccardi III, PhD Iqbal J, Sun L, Kumar TR, Blair HC, Zaidi M. Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci USA 2006;103:14925-14930. Clinical Research Article: Allyson K. McDonough, MD De Benedetti F, Rucci N, Del Fattore A, Peruzzi B, Paro R, et al. Impaired Skeletal Development in Interleukin-6-Transgenic Mice: A Model for the Impact of Chronic Inflammation on the Growing Skeletal System. Arthritis Rheum 2006;54:3551-3563.
03/01/07	Basic Research Article: Majd Zayzafoon, MD, PhD Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, et al. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 2006;12:1410-1416. Clinical Research Article: Kenneth G. Saag, MD, MSc Richards JB, Papaioannou A, Adachi JD, Joseph L, et al. Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture. Arch Intern Med 2007;167:188-194. Yang Y, Lewis JD, Epstein S, Metz DC. Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture. JAMA 2006;296:2947-2953.
04/05/07	Basic Research Article: Hui Wu, PhD Diarra D, Stolina M, Polzer K, Zwerina J, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 2007;13:156-163. Clinical Research Article: Shawn R. Gilbert, MD Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, et al., for the Health, Aging and Body Composition (Health ABC) Study. Thiazolidinedione Use and Bone Loss in Older Diabetic Adults. J Clin Endocrinol Metab 2006;91:3349-3354.
05/03/07	Basic Research Article: Melissa A. Talbert Saita Y, Takagi T, Kitahara K, Usui M, et al. Lack of Schnurri-2 Expression Associates with Reduced Bone Remodeling and Osteopenia. J Biol Chem 2007;282:12907-12915. Clinical Research Article: Donald H. Lein, MS, PT Kato T, Terashima T, Yamashita T, Hatanaka Y. Effect of low-repetition jump training on bone mineral density in young women. J Appl Physiol 2006;100:839-843
06/07/07	Basic Research Article: CMBD Postdoctoral Fellow (to be announced) Clinical Research Article: Robert R. Lopez, MD
09-06-07	Basic Research Article: Alan W. Eberhardt, PhD. Clinical Research Article: Robert R. Lopez, MD. Callstrom MR, Atwell TD, Charboneau JW, Farrell MA, et al. Painful Metastases Involving Bone: Percutaneous Image-guided Cryoablation—Prospective Trial Interim Analysis. Radiology 2006;241:572-580. Articles:
10-18-07	Basic Research Article: Douglas J. DiGirolamo Clinical Research Article: Jeffrey R. Curtis, MD. Articles: To be determined
11-01-07	Basic Research Article: Hui Wu, PhD. Clinical Research Article: Sarah L. Morgan, MD, RD, FACA, FACP. Articles: To be determined
12-06-07	Basic Research Article: Anthony J. Siccardi, PhD. Clinical Research Article: Elizabeth M. Kitchin, BS, MS, RD. Articles: To be determined

2006
01/05/06	Basic Research Article: Carrie A. Elzie Schroeder TM, Westendorf JJ. Histone Deacetylase Inhibitors Promote Osteoblast Maturation. J Bone Miner Res 2005;20:2254-2263. Clinical Research Article: Shawn R. Gilbert, MD Govender S, Csimma C, Genant HK, Valentin-Opran A. Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty Patients. J Bone Joint Surg Am 2002;84:2123-2134.
02/02/06	Basic Research Article: Alan W. Eberhardt, PhD Silva MJ, Brodt MD, Hucker WJ. Estimating Endocortical Strain During Three-Point Bending in SAMP6 Osteoporotic Mice. Anat Rec A 2005:283A:380-390. Clinical Research Article: Jeffrey D. Faggard, MD Grant AM, Avenell A, Campbell MK, McDonald AM, et al. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 2005;365:1621-1628.
03/02/06	Basic Research Article: Majd Zayzafoon, MD, PhD Dayer R, Rizzoli R, Kaelin A, Ammann P. Low Protein Intake Is Associated With Impaired Titanium Implant Osseointegration. J Bone Miner Res 2006;21:258-264. Clinical Research Article: Gregory Batson, MD Jackson RD, LaCroix AZ, Gass M, Wallace RB, et al. Calcium plus Vitamin D Supplementation and the Risk of Fractures. N Engl J Med 2006;354:669-683.
04/06/06	Basic Research Article: Emily Duff, Licensing Associate; W. S. (Sandy) White, CEO, The UAB Research Foundation “Why Should I Care? Case-Studies on University Intellectual Property” Clinical Research Article: Monica Adams, MD McClung MR, Lewiecki EM, Cohen SB, Bolognese MA, et al. Denosumab in Postmenopausal Women with Low Bone Mineral Density. N Engl J Med 2006;354:821-831.
05/04/06	Basic Research Article: Hui Wu, PhD Liu PT, Stenger S, Li H, Wenzel L, et al. Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response. Science 2006;311:1770-1773. Clinical Research Article: Angelo Gaffo, MD Giovannucci E, Liu Y, Rimm EB, Hollis BW, et al. Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men. J Natl Cancer Inst 2006;98:451-459.
06/01/06	Basic Research Article: Derrick R. Dean, PhD Thomas V, Jagani S, Johnson K, Jose MV, Dean DR, Vohra YK, Nyairo E. Electrospun Bioactive Nanocomposite Scaffolds of Polycaprolactone and Nanohydroxyapatite for Bone Tissue Engineering. J Nanosci Nanotechnol 2006;6:487-493. Clinical Research Article: Amy Warriner, MD Wuttke W, Gorkow C, Seidlová-Wuttke D. Effects of black cohosh (Cimicifuga racemosa) on bone turnover, vaginal mucosa, and various blood parameters in postmenopausal women: A double-blind, placebo-controlled, and conjugated estrogens-cnotrolled study. Menopause 2006;13:185-196.
09/07/06	Basic Research Article: Amjad Javed, PhD Gersbach CA, Le Doux JM, Guldberg RE, Garcia AJ. Inducible regulation of Runx2-stimulated osteogenesis. Gene Therapy 2006;13:873-882. Clinical Research Articles: Jeffrey R. Curtis, MD, MPH Siris ES, Harris ST, Rosen CJ, Barr CE, et al. Adherence to Bisphosphonate Therapy and Fracture Rates in Osteoporotic Women: Relationship to Vertebral and Nonvertebral Fractures From 2 US Claims Databases. Mayo Clin Proc 2006;81(8):1013-1022. Siris ES, Brenneman SK, Barrett-Connor E, Miller PD, et al. The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50-99: results from the National Osteoporosis Risk Assessment (NORA). Osteoporos Int 2006;17:565-574.
10/05/06	Basic Research Article: Douglas J. DiGirolamo Windahl SH, Galien R, Chiusaroli R, Clément-Lacroix P, et al. Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor. J Clin Invest 2006;116:2500-2509. Clinical Research Article: Elizabeth M. Kitchin, BS, MS, RD Lin PH, Ginty F, Appel LJ, Aickin M, et al. The DASH Diet and Sodium Reduction Improve Markers of Bone Turnover and Calcium Metabolism in Adults. J Nutr 2006;133:3130-3136.
11/02/06	Basic Research Article: Girish Ramaswamy Balooch G, Balooch M, Nalla RK, Schilling S, et al. TGF-ß regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci USA 2005;102:18813-18818. Clinical Research Article: Gim Gee Teng, MD van Staa TP, Geusens P, Bijlsma JWJ, Leufkens HGM,Cooper C. Clinical Assessment of the Long-Term Risk of Fracture in Patients With Rheumatoid Arthritis. Arthritis Rheum 2006;54:3104-3112.
12/07/06	Basic Research Article: N. Robert Estes, PhD Liao J, Schneider A, Datta NS, McCauley LK. Extracellular Calcium as a Candidate Mediator of Prostate Cancer Skeletal Metastasis. Cancer Res 2006;66:9065-9073. Special Clinical Topic: Robert W. Hardy, PhD Is Procollagen Type 1 N-Terminal Propeptide (P1NP) an Effective Marker for Monitoring Response to Antiresorptive Medications?”
2005
01/06/05	Basic Research Article: Gene P. Siegal, MD, PhD Porter DE, Lonie L, Fraser M, Dobson-Stone C, et al. Severity of disease and risk of malignant change in hereditary multiple exostoses. A genotype-phenotype study. J Bone Joint Surg Br 2004;86:1041-1046. Clinical Research Article: Robert W. Hardy, PhD Hollis BW. Comparison of commercially available 125I-based RIA methods for the determination of circulating 25-hydroxyvitamin D. Clin Chem 2000;46:1657-1661.
02/03/05	Basic Research Article: Carrie A. Elzie, BS Miura M, Chen X-D, Allen MR, Bi Y, et al. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. J Clin Invest 2004;114:1704-1713. Clinical Research Article: Sarah L. Sampsel, MPH Solomon DH, Brookhart MA, Gandhi TK, Karson A, et al. Adherence with osteoporosis practice guidelines: A multilevel analysis of patient, physician, and practice setting characteristics. Am J Med 2004;117:919-924.
03/03/05	CASE DISCUSSION – 3:30-5:30 pm Coordinator: Eric S. Albright, MD Guest: Nelson B. Watts, MD Director, University of Cincinnati Bone Health and Osteoporosis Center
04/07/05	Basic Research Article: Michael J. Teale, PhD Corey E, Brown LG, Kiefer JA, Quinn JE, et al. Osteoprotegerin in Prostate Cancer Bone Metastasis. Cancer Res 2005;65:1710-1718. Clinical Research Article: Jeffrey R. Curtis, MD, MPH Nordin BEC, Need AG, Morris HA, O’Loughlin PD, Horowitz M. Effect of age on calcium absorption in postmenopausal women. Am J Clin Nutr 2004;80:998-1002. Smith E, Need AG, Schultz CG, Horowitz M. Does the response of bone mass to calcium supplements depend on calcium absorption efficiency? Eur J Endocrinol 2004;151:759-763.
05/05/05	Basic Research Article: Ji-Ben Peng, PhD Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, et al. Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 2003;112:1906-1914. Clinical Research Article: Joel D. Abbott, MD Bauer DC, Black DM, Garnero P, Hochberg M, et al. Change in Bone Turnover and Hip, Non-Spine, and Vertebral Fracture in Alendronate-Treated Women: The Fracture Intervention Trial. J Bone Miner Res 2004;19:1250-1258.
06/02/05	Basic Research Article: Xu Feng, PhD Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest 2005;115:282-290. Clinical Research Article: Kenneth G. Saag, MD, MPH Kasperk C, Hillmeier J, Nöldge G, Grafe IA, et al. Treatment of Painful Vertebral Fractures by Kyphoplasty in Patients With Primary Osteoporosis: A Prospective Nonrandomized Controlled Study. J Bone Miner Res 2005;20:604-612.
09/01/05	Basic Research Article: April Adams Kelly T, Suva LJ, Huang Y, MacLeod V, et al. Expression of Heparanase by Primary Breast Tumors Promotes Bone Resorption in the Absence of Detectable Bone Metastases. Cancer Res 2005; 65:5778-5784. Clinical Research Article:Sarah L. Morgan, MD, RD, FADA, FACP Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the Jaws Associated With the Use of Bisphosphonates: A Review of 63 Cases. J Oral Maxillofac Surg 2004; 62:527-534.
10/06/05	Basic Research Article: Stephanie Cowey, PhD Lynch CC, Hikosaka A, Acuff HB, Martin MD, et al. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell 2005;7:485-496. Clinical Research Article: Gim Gee Teng, MD Cosman F, Nieves J, Zion M, Woelfert L, Luckey M, Lindsay R. Daily and Cyclic Parathyroid Hormone in Women Receiving Alendronate. N Engl J Med 2005;353:566-575.
11/03/05	Basic Research Article: Katri Selander, MD, PhD Miwa S, Mizokami A, Keller ET, Taichman R, et al. The Bisphosphonate YM529 Inhibits Osteolytic and Osteoblastic Changes and CXCR-4-Induced Invasion in Prostate Cancer. Cancer Res 2005;65:8818-8825. Clinical Research Article: Steven M. Theiss, MD Lai KA, Shen WJ, Yang CY, Shao CJ, et al. The Use of Alendronate to Prevent Early Collapse of the Femoral Head in Patients with Nontraumatic Osteonecrosis. J Bone Joint Surg Am 2005;87-A:2155-2159.
12/01/05	Basic Research Article: Amber A. Sawyer Schantz JT, Brandwood A, Hutmacher DW, Khor HL, Bittner K. Osteogenic differentiation of mesenchymal progenitor cells in computer designed fibrin-polymer-ceramic scaffolds manufactured by fused deposition modeling. J Mater Sci Mater Med 2005;16:807-819. Clinical Research Article: Sumapa Chaiamnuay, MD Tankó LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR. Relationship Between Osteoporosis and Cardiovascular Disease in Postmenopausal Women. J Bone Miner Res 2005;20:1912-1920.
2004
01/08/04	Basic Research Article: C. Jeff Crews Eghbali-Fatourechi G, Khosla S, Sanyal A, et al. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 2003;111:1221-1230. Clinical Research Article: Sarah L. Morgan, MD, RD, FADA, FACP Diamond TH, Champion B, Clark WA. Management of Acute Osteoporotic Vertebral Fractures: A Nonrandomized Trial Comparing Percutaneous Vertebroplasty with Conservative Therapy. Am J Med 2003;114:257-265.
02/05/04	Basic Research Article: Carrie A. Elzie Faccio R, Novack DV, Zallone A, Ross FP, Teitelbaum SL. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by ß3 integrin. J Cell Biol 2003;162:499-509. Clinical Research Article: Eric S. Albright, MD Rescheduled for 04-01-04.
03/04/04	Special Speaker: Joseph A. Lorenzo, MD, Professor of Medicine, Division of Endocrinology, University of Connecticut Health Center Title: Role of B-Lymphopoesis in Osteoclastogenesis
04/01/04	Basic Research Presentation: Valerie Meyers The effects of modeled microgravity on osteoblastogenesis Clinical Research Article: Eric S. Albright, MD Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, et al. Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab 2001;86:32-38.
05/06/04	Special Speaker: Karen Lyons, PhD, Associate Professor of Orthopaedic Surgery, Biological Chemistry, and Molecular, Cell & Developmental Biology, UCLA Title: Coordination of Growth Plate Morphogenesis by BMP and FGF Signaling Pathways.
06/03/04	Basic Research Article: Stephanie L. Cowey, PhD Morgan H, Tumber A, Hill PA. Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor. Int J Cancer 2004;109:653-660. Clinical Research Article: Thomas G. Wimmer, MD Bone HG, Hosking D, Devogelaer J-P, Tucci JR, et al. Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med 2004;350:1189-1199.
09/16/04	UAB CAMPUS CLOSED - Meeting canceled.
10/07/04	Basic Research Article: Selvarangan Ponnazhagan, PhD Yang S-Y, Wu B, Mayton L, Mukherjee P, et al. Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis. Gene Ther 2004;11:483-491. Clinical Research Article: Keivan Dehghanpisheh, MD, PhD Akune T, Ohba S, Kamekura S, Yamaguchi M, et al. PPARy. insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004;113:846-855.
11/04/04	Basic Research Article: Amber A. Sawyer Reyes CD, Garcia AJ. a2ß1 Integrin-specific collagen-mimetic surfaces supporting osteoblastic differentiation. J Biomed Mater Res 2004;69A:591-600. Clinical Research Article: Henry B. Townsend, MD Schlienger RG, Kraenzlin ME, Jick SS, Meier CR. Use of ß-blockers and risk of fractures. JAMA 2004;292:1326-1332.
12/02/04	Basic Research Article: Aditi Mukherjee Dacquin R, Davey RA, Laplace C, Levasseur R, et al. Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. J Cell Biol 2004;164:509-514. Clinical Research Article: Michael J. Klein, MD Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 2004;165:1773-1780.
2003
01/09/03	Special Speaker: Nelson B. Watts, MD, Professor of Medicine and Director, Osteoporosis Center. Title: The Ethics of Placebo Control Trials for Osteoporosis Therapy.
02/06/03	Basic Research Article: Xu Cao, PhD Borton A, Frederick J, Datto M, Wang X-F, Weinstein R. The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis. J Bone Miner Res 2001;16:1754-1764 Clinical Research Article: Sarah L. Morgan, MD, RD, FADA, FACP Shiomi S, Nishiguchi S, Kubo S, Tamori A, et al. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. Am J Gastroenterol 2002;97:978-981.
03/06/03	Special Speaker: J. Edward Puzas, PhD Donald and Mary Clark Porfessor of Orthopaedics, University of Rochester School of Medicine and Denistry. Title: Molecular Methods Identify Novel Regulators of Osteoblast Function: Possible Targets for the Treatment of Osteoporosis.
04/03/03	Basic Research Article: John D. Mountz, MD, PhD Palomba S, Numis FG, Mossetti G, Rendina D, et al. Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with Bsml vitamin D receptor genotypes. Clin Endocrinol 2003;58:365-371. Shimizu M, Higuchi K, Kasai S, Tsuboyama T, et al. A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density. Mamm Genome 2002;13:335-340. Clinical Research Article: Jeffrey R. Curtis, MD Body J-J, Gaich GA, Scheele WH, Kulkarni PM, et al. A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)].J Clin Endocrinol Metab 2002;87:4528-4535. Marcus R, Wang O, Satterwhite, J, Mitlak B. The skeletal response to teriparatide is largely independent of age, initial bone mineral density, and prevalent vertebral fractures in postmenopausal women with osteoporosis. J Bone Miner Res 2003;18:18-23. Orwoll ES, Scheele WH, Paul S, Adami S, et al. The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis. J Bone Miner Res 2003;18:9-17.
05/01/03	Special Speaker: Robert W. Downs, Jr., MD, Professor of Medicine, Virginia Commonwealth University School of Medicine Title: Paget’s Disease and Fibrous Dysplasia
06/05/03	Basic Research Article: Amanda T. Boyce, PhD Settle SH Jr, Rountree RB, Sinha A, Thacker A, Higgins K, Kingsley DM. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol 2003;254:116-130. Clinical Research Article: Elizabeth M. Kitchin, BS, MS, RD Jensen C, Holloway L, Block G, Spiller G, Gildengorin G, Gunderson E, Butterfield G, Marcus R. Long-term effects of nutrient intervention on markers of bone remodeling and calciotropic hormones in late-postmenopausal women. Am J Clin Nutr 2002;75:1114-1120.
09/04/03	Basic Research Article: Gene P. Siegal, MD, PhD Corsi A, Collins MT, Riminucci M, Howell PGT, et al. Osteomalacic and hyperparathyroid changes in fibrous dysplasis of bone. JBMR 2003;18:1235-1246. Clinical Research Article: Kenneth G. Saag, MD MSc Whyte MP, Wenkert D, Clements KL, McAlister WH, Mumm S. Bisphosphonate-induced osteoperosis. N Engl J Med 2003;349:457-463.
10/02/03	Special Speaker: Robert S. Weinstein, MD, Professor of Medicine, Director, Bone Histomorphometry Laboratory, University of Arkansas for Medical Sciences Title: Glucocorticoid Action in Bone
11/06/03	Basic Research Article: Jay M. McDonald, M.D. Abe E, Marians RC, Yu W, Wu XB, Ando T, et al. TSH Is a Negative Regulator of Skeletal Remodeling: Cell 2003;115:151-162. Clinical Research Article: Nasser Said-Al-Naief, D.D.S. Kocher MS, Kasser JR. A Review Paper: Osteopetrosis. Am J Orthop 2003;May:222-228
12/04/03	Special Speaker: Laura D. Carbone, MS, MD, Associate Professor of Medicine and Director, Memphis Metabolic Bone Center, University of Tennessee College of Medicine Title: The Relationship of Sodium Intake to Bone Health
2002
1/3/02	Basic Research Article: Pi-Ling Chang, PhD Perlot RL Jr, Shapiro IM, Mansfield K, Adams CS. Title: Matrix regulation of skeletal cell apoptosis II: Role of arg-gly-asp-containing peptides. J Bone Miner Res 2002;17:66-76 Clinicial Research Article: Ted R. Mikuls, MD Oinuma K, Harada Y, Nawata Y, Takabayashi K, Abe I, Kamikawa K, Moriya H. Title: Osteonecrosis in patients with systemic lupus erythematosus develps very early after starting high dose corticosteroid treatment. Ann Rheum Dis 2001;60;1145-1148
2/7/02	Basic Research Article: Joanne T. Douglas, PhD Matsubara S, Wada Y, Gardner TA, et al. Title: A conditional replication-competent adenoviral vector, Ad-OC-Ela, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res 2001;61:6012-6019 Clinicial Research Article: Marcin Gornisiewica, MD de Nijs RNJ, Jacobs JWG, Bijlsma JWJ, et al. Title: Prevalence of vertabral deformities and symptomatic rheumatoid arthritis. Rheumatology 2001;40:1375-1383
3/7/02	Basic Research Article: Selvarangan Pannazhagan, PhD Baltzer AWA, Whalen JD, Wooley P, et al. Title: Gene therapy for osteoporosis: evaluation in a murine ovariectomy model. Gene Therapy 2001;8:1770-1776 Clinicial Research Article: Catherine Daniel, MD Siris ES, Miller PD, Barrett-Conner E, et al. Title: Identificaiton and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women. JAMA 2001;826:28815-2822
4/4/02	Special Speaker: Ernst B. Hunziker, MD, Professor and Chairman, M.E. Müller Institute for Biomechanics, Unversity of Bern, Ber, Switzerland. Title: Tissue Engineering Approaches for Articular Cartlige Repair
5/2/02	Basic Research Article: Joanne E. Murphy-Ullrich, PhD Heino TJ, Hentunen TAS, Väänänen HK. Title: Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-ß: Enhancement by estrogen. J Cell Biochem 2002;85:185-197 Clinicial Research Article: Sattar A.Hadi, MD Fogelholm GM, Sievänen HT, Kukkonen-Harjula TK, Pasanen ME. Title: Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women. Osteoporos Int 2001;12:199-206
6/6/02	Basic Research Article: Mary Ann Accavitti, PhD Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R. Title: Up-regulation of TNF-producing Tcells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo. PNAS 2001, 98:13960-13965. Clinicial Research Article: Nadine James, PhD Wu CH, Yang YC, Yao WJ, Lu FH, Wu JS, Chang CJ. Title: Epidemiological evidence of increased bone mineral density in habitual tea drinkers. Arch Intern Med 2002;162:1001-1006
9/5/02	Basic Research Article: Katri S. Selander, MD, PhD Käkönen S-M, Selander KS, Chirgwin JM, Yin JJ, et al. Title: Transforming growth factor-ß stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. J Biol Chem 2002;277:24571-24578 Clinicial Research Article: Jason Olivieri, MPH Writing group for the Women's Health Initiative Investigators (Rossouw SE, Anderson GL, Prentice RL, et al.) Title: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial. JAMA 2002;288:321-333.
10/3/02	Special Speaker: Nancy E. Lane, PhD Associate Professor in Residence of Medicine and Rheumatology, University of California, San Francisco. Title: A New Paradigm for Osteoporosis Treatment
11/7/02	Basic Research Article: Robert W. Hardy, PhD Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH. Title: Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells 2002;20:249-258. Clinical Research Article:Amie B. Jackson, MD Garland DE, Adkins RH, Stewart CA, Ashford R, Vigil D. Title: Regional osteoporosis in women who have a complete spinal cord injury. J Bone Joint Surg 2001;83-A:1195-1200
12/05/02	Basic Research Article: Majd Zayzafoon, MD, PhD Narayanan R, Smith CL, Weigel NL, Vector-averaged gravity-induced changes in cell signaling and vitamin D receptor activity in MG-63 cells are reversed by a 1,25-(OH)2D3 analog, EB1089. Bone 2002;31:381-388. Clinical Research Article: Sonia Bajaj, MD Abrahamsen B, Nissen N, Hermann AP, Hansen B, et al. When should densitometry be repeated in healthy peri- and postmenopausal woman: The Danish ostoporosis prevention study. J Bone Miner Res 2002;17:2061-2067

2001
1/4/01	Basic Research Article: Shuting Bai Zhang Y-W, Yasui N, Ito K, Huang G, Fujii M, Hanai J-I, Nogami H, Ochi T, Miyazono K, Ito Y. Title: A RUNX2/PEBP2alphaA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A 2000;97:10549-10554. Clinicial Research Article: Sarah Morgan, MD, RD, FACP Mitchell DY, Heise MA, Pallone KA, Clay ME, Nesbitt JD, Russell D, Melson C. Title: The effect of dosing regimen on the pharmacokinetics of risedronate. Br J Clin Pharmacol1999;48:536-542. Lanza FL, Hunt RH, Thomson ABR, Provenza JM, Blank MA Title:Endoscopic comparison of esophageal and gastroduodenal effects of risedronate and alendronate in postmenopausal women. Gastroenterology 2000;119:631-638.
2/1/01	Basic Research Article: Cancelled Clinicial Research Article: Cora E. Lewis, MD Cummings SR, Palermo L, Browner W, Marcus R, Wallace R, Pearson J, Blackwell T, Eckert S, Black D. Title:Monitoring osteoporosis therapy with bone densitometry. JAMA 2000;283:1318-1321.
3/1/01	Basic Research Article: Xu Feng, PhD Kornak U, Kasper D, Bösl MR, Kaiser E, Schweizer M, Schulz A, Friedrich W, Delling G, Jentsch TJ Title: Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man. Cell 2001;104:205-215. Clinicial Research Article: Kenneth M. McCormick, MD Meghji S, Morrison MS, Henderson B, Arnett TR. Title: pH dependence of bone resorption: Mouse calvarial osteoclasts are activated by acidosis. Am J Physiol Endocrinol Metab 2001;280:E112-E119.
4/5/01	Basic Research Article: Liang Zhang, PhD Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. Title: TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000;106:1481-1488. Clinicial Research Article: Jay M. McDonald, MD Tebas P, Powderly WG, Claxton S, Marin D, Tantisiriwat W, Teitelbaum SL, Yarasheski KE. Title: Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS 2000;14:F63-F67. General Reference - Clinical Research Article Mynarick DC, McNurlan MA, Steigbigel RT, Fuhrer J, Gelato MC. Title: Association of severe insulin resistance with bone loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy. J Acquir Immune Defic Syndr 2000;25:312-321.
5/3/01	Special Speaker: Jay Shapiro, MD, Professor, Department of Medicine, and Director, Interdepartmental Center for Space Medicine, Uniformed Services University of the Health Sciences, and Director, Osteogenesis Imperfecta Clinic, The Kennedy Krieger Institute Title: : Bone Loss and the Trip to Mars.
6/7/01	Basic Research Article: Gene P. Siegal, MD, PhD Bolon B, Carter C, Daris M, Morony S, Capparelli C, Hsieh A, Mao M, Kostenuik P, Dunstan CR, Lacey DL, Sheng JZ. Title: Adenvorial delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis. Mol Therapy 2001;3:197-205. Clinicial Research Article: Laura Hughes, MD Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster-J-Y, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH. Title: Effects of parathyroid hormone (1-34) on fractures and bone mineral desnity in postmenopausal women with osteoporosis. N Engl J Med 2001;344;1434-1441.
9/6/01	Special Speaker: Ernesto Canalis, MD, Professor, Department of Research St. Francis Hospital Medical Center, Hartford, Connecticut. Title: Mechanisms of Glucocorticoid Action in Bone: relevance to Glucocorticoid Induced Osteoporosis. Title: Role of Growth Factors and Their Antagonist in Bone Cell Function.
10/4/01	Basic Research Article: Stacye Kelpke, PhD Jasiwal RK, Jaiswal N, Bruder SP, Mbalaviele G, Marshak DR, Pittenger MF. Title: Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J Biol Chem 2000;275:9645-9652. Clinicial Research Article: Richard J. Misischia, MD Harris ST, Eriksen EF, Davidson M, Ettinger MP, Moffett, Jr. AH, Baylink DJ, Crusan CE, Chines AA. Title: Effect of combined risedronate and hormone replacement therapies on bone mineral density in postmenopausal women. J Clin Endocrinol Metab 2001;86;1890-1897.
11/1/01	Special Speaker: Robert P. Heaney MD John A. Creighton, University Professor, Creighton University, Omaha, Nebreska Title: Nutrition Co-Therapy for Osteoporosis: The Naamam Complex. Title: How Much Vitamin D Do We Need ? And Where Shall We Get It ?
12/6/01	Basic Research Article: Nasser Said-Al-Naief, DDS Dieudonne SC, Foo P, Van Zoelen EJJ, Burger EH. Title: Inhibiting and stimulating effects of TGF-ß1, on osteoclastic bone resorption in fetal mouse bone organ cultures. J Bone Miner Res 1991;6:479-487. Clinicial Research Article: Kenneth G. Saag, MD Israel E, Banerjee TR, Fitzmaurice GM, Kotlov TV, LaHive K, LeBoff MS. Title: Effect of inhaled glucocorticoids on bone density in premeneopausal women. N Engl J Med 2001;345;941-947

2000
1/6/00	Basic Research Article: Kirsten Larsen, BA Villanova I, Townsend PA, Uhlmann E, Knolle J, Peyman A, Amling M, Baron R, Horton MA, Teti A. Title: Oligodeoxynucleotide targeted to the alpha-v gene inhibits alpha-v integrin synthesis, impairs osteoclast function, and activates intracellular signals to apoptosis. J Bone Miner Res 1999;14:1867-1879. General Reference - Basic Research Article Hughes DE, Boyce BF. Title: Apoptosis in bone physiology and disease. J Clin Pathol: Mol Pathol 1997;50:132-137. Clinicial Research Article: Amy Mudano, MPH Buckley LM, Marquez M, Feezor R, Ruffin DM, and Benson LL. Title: Prevention of corticosteroid-induced osteoporosis. Results of a patient survey. Arthritis Rheum 1999;42:1736-1739. Aagaard EM, Lin P, Modin GW, and Lane NE. Title: Prevention of glucocorticoid-induced osteoporosis: provider practice at an urban county hospital. Am J Med 1999;107:456-460.
3/2/00	Basic Research Article: Timothy R. Nagy, PhD Nagy TR, Clair A-L. Title: Precision and accuracy of dual-energy x-ray absorptiometry for determining in vivo body composition of mice. Obesity Research 2000 (in press). Clinicial Research Article: Michael S. McCracken, DDS, PhD Masuda T, Salvi GE, Offenbacher S, Felton DA Cooper LF Title:Cell and matrix reactions at titanium implants in surgically prepared rat tibiae. Int J Oral Maxillofac mplants 1997;12:472-485.
4/6/00	Basic Research Article: Harry C. Blair, MD Risser F, Pfister CU, Degen PH. Title: An enzyme inhibition assay for the quantitative determination of the new bisphosphonate zoledronate in plasma. J Pharm Biomed Anal. 1997;15:1877-1880. Shipman CM, Croucher PI, Russell RGG, Helfrich MH, Rogers MJ. Title: The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer Res 1998;58:5294-5297. Clinicial Research Article: Kenneth G. Saag, MD, MSc Hochberg MC, Ross PD, Black D, Cummings SR, Genant HK, Nevitt MC, Barrett-Connor E, Musliner T, Thompson D. Title: Larger increases in bone mineral density during alendronate therapy are associated with a lower risk of new vertebral fractures in women with postmenopausal osteoporosis .Arthritis Rheum 1999;42:1246-1254. Wasnich RD, Miller PD. Title: Anti-fracture efficacy of antiresportive agents are related to changes in bone density. J Clin Endocrinol Metab 2000;85:231-236
5/4/00	Basic Research Article: Xingming Shi, PhD Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Title: Stimulation of bone formation in vitro and in rodents by statins. Science 1999;286:1946-1949. Clinicial Research Article: Sarah L. Morgan, MD, RD, FACP Ensrud KE, Duong T, Cauley JA, Heaney RP, Wolf RL, Harris E, Cummings SR Title: For the Study of Osteoporotic Fractures Research Group: Low fractional calcium absorption increases the risk for hip fracture in women with low calcium intake. Ann Intern Med 2000;132:345-353.
6/1/00	Basic Research Article: John P. Williams, PhD Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G. Title: Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell 2000;100:197-207. Clinicial Research Article: Bruce P. Wheatley, PhD Stojanowski C, Seidemann R. Title: A reevaluation of the sex prediction accuracy of the minimum supero-inferior femoral neck diameter for modern individuals. J Forensic Sci 1999;44:1215-1218.
9/7/00	Basic Research Article: Jay M. McDonald, MD Canalis E Title: Novel treatments for osteoporosis. J Clin Invest 2000;106:177-179. General Reference - Basic Research Article Visentin L, Dodds RA, Valente M, Misiano P, Bradbeer JN, Oneta S, Liang X, Gowen M, Farina C. Title: A selective inhibitor of the osteoclastic V-H+-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats. J Clin Invest 2000;106:309-318. Gowen M, Stroup GB, Dodds RA, James IE, Votta BJ, Smith BR, Bhatnagar PK, Lago AM, Callahan JF, DelMar EG, Miller MA, Nemeth EF, Fox F. Title: Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. J Clin Invest 2000;105:1595-1604. Clinicial Research Article: Andrea Ohldin, MD Nevitt M, Thompson DE, Black DM, Rubin SR, Ensrud K, Yates AJ, Cummings SR. Title: Effect of alendronate on limited-activity days and bed-disability days caused by back pain in postmenopausal women with existing vertebral fractures. Arch Intern Med 2000;160:77-85.
10/5/00	Basic Research Article: Susan L. Bellis, PhD Ozawa S, Kasugai S. Title: Evaluation of implant materials (hydroxyapatite, glass-ceramics, titanium) in rat bone marrow stromal cell culture. Biomaterials 1996;17:23-29. Clinicial Research Article: Daniel S. Moore, MD Gulam M, Thornton MM, Hodsman AB, Holdsworth DW. Title: Bone mineral measurement of phalanges: Comparison of radiographic absorptiometry and area dual X-ray absorptiometry. Radiology 216:586-591, 2000.
11/2/00	Basic Research Article: Marjorie K. Jeffcoat, DMD Cortellini P, Pini Prato G, Tonetti MS. Title: Periodontal regeneration of human intrabony defects with titanium reinforced membrane: a controlled clinical trial. J Periodontol 1995;66:797-803. Clinicial Research Article: Ali Ahmed, MD Orr-Walker BJ, Evans MC, Clearwater JM, Horne A, Grey AB, Reid AR Title: Effects of hormone replacement therapy on bone mineral density in postmenopausal women with primary hyperparathyroidism. Arch Intern Med 2000;160:2161-2166.
12/7/00	Basic Research Article: Wen-Cheng Xiong, MD, PhD Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, Choi Y. Title: TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Molecular Cell 1999;4:1041-1049. Clinicial Research Article: Kenneth G. Saag, MD, MSc Naganathan V, Jones G, Nash P, Nicholson G, Eisman J, Sambrook PN. Title:Vertebral fracture risk with long-term corticosteroid therapy. Arch Intern Med 2000:160:2917-2922.

1999
2/4/99	Basic Research Article: Harry C. Blair, MD Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, Van Der Saag PT, Van Der Burg B, Gustafsson J-A. Title: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor ß. Endocrinology 1998;139(10):4252-4263. Clinicial Research Article: Kenneth G. Saag, MD Delmas PD, Bjarnason NH, Mitlak BH, Ravoux AC, Shah AS, Huster WJ, Draper M, Christiansen C. Title: Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 1997;337(23):1641-1647. General Reference Article Jordan VC. Title: Designer estrogens: Sci Am 1998;279(4):60-67.
3/4/99	Basic Research Article: John P. Williams, PhD Kong Y-Y, Yoshida H, Sarosi I, et al. Title: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397:315-323. General Reference:- Basic Research Article Teitelbaum SL, Abu-Amer Y, Ross FP Title: Molecular mechanisms of bone resorption. J Cell Biochem 1995;59:1-10. Clinicial Research Article: Jay M. McDonald, MD Chesnut CH, Bell NH, Clark GS, et al. Title: Hormone replacement therapy in postmenopausal women: Urinary N-telopeptide of Type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med 1997;102:29-37. General Reference: Clinical Research Article: Christenson RH Title: Biochemical markers of bone metabolism: An overview. Clin Biochem 1997;30:573-593.
5/6/99	Basic Research Article: Helen Kim, PhD Goetz RM, Thatte HS, Prabhaker P, Cho MR, Michel T, Golan DE. Title: Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci 1999;96:2788-2793. Clinicial Research Article: : Sarah L. Morgan, MD, RD, FACP Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA. Title: Vitamin K intake and hip fractures in women: A prospective study. Am J Clin Nutr 1999;69:74-79.
6/3/99	Basic Research Article: Alan W. Eberhardt, PhD Brown TD, Way ME, Ferguson AB Jr. Title:Mechanical characteristics of bone in femoral capital aseptic necrosis. Clin Orthop Rel Res 1981;156:240-247. Brown TD, Baker KJ, Brand RA Title: Structural consequences of subchondral bone involvement in segmental osteonecrosis of the femoral head. J Orthop Res 1992;10:79-87. Clinicial Research Article: Bruce A. Julian, MD. Ramsey-Goldman R, Dunn JE, Dunlop DD, Stuart FP, Abecassis MM, Kaufman DB, Langman CB, Salinger MH, Sprague SM. Title: Increased risk of fracture in patients receiving solid organ transplants. J Bone Miner Res 1999;14:456-463.
9/2/99	Basic Research Article: Xu Cao, PhD Pittenger M, Mackay A, Beck S, Jaiwal R, Douglas R, Mosca J, Moorman M, Simonetti D, Craig S, Marshak D. Title: Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-146. General Reference - Basic Research Article Prockop DJ Title: Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74. Clinicial Research Article: Elizabeth M. Kitchin, BS, MS, RD Heaney RP, Dowell MS, Barger-Lux MJ. Title: Absorption of calcium as the carbonate and citrate salts, with some observations on method. Osteoporos Int. 1999;9:19-23. General Reference: Clinical Research Article: Recker RR, Bammi A, Barger-Lux MF. Title: Calcium absorbability from milk products, an imitation milk, and calcium carbonate. Am J Clin Nutr. 1988;47:93-95.
10/7/99	Basic Research Article: Dale S. Feldman, PhD Win S, Schmidt J, Buck D, Hu Y, Grainger D, and Hollinger, J. Title: Tissue-engineered bone biomimetic to regenerate calvarial critical-sized defects in athymic rats. J Biomed Mater Res 1999; 45(4):414-421. General Reference - Basic Research Article Damien C. and Parsons J. Title: Bone graft and bone graft substitutes: A review of current technology and applications. J Applied Biomaterials 1991;2:187-208. Donkerwolcke M. and Muster B. Title: Tissue and bone adhesives: Historical aspects. Biomaterials 1998;19:1461-1466. Clinicial Research Article: Robert R. Lopez, MD Jensen ME, Evans AJ, Mathis JM, Kallmes DF, Cloft HJ, and Dion JE. Title: Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: Technical aspects. Am J Neuroradiol 1997;18:1897-1904.
12/2/99	Basic Research Article: Richard Mayne, PhD Lee ER, Murphy G, El-Alfy M, Davoli MA, Lamplugh L, Docherty AJ, Leblond CP. Title: Active gelatinase B is identified by histozymography in the cartilage resorption sites of developing long bones. Dev Dyn 1999;215:190-205. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. Title: MMP-9'Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 1998;93:411-422. Clinicial Research Article: Don Lein, MS, PT Sinaki M, Fitzpatrick LA, Ritchie CK, Montesano A, Wahner HW. Title: Site specificity of bone mineral density and muscle strength in women; job-related physical activity. Am J Physical Med Rehab 1998;77:470-476.