UASOM Faculty Profiles

Faculty Detail

Name: Mary J. MacDougall, Ph.D.

Rank: Professor and Associate Dean of Research

Campus Address: SDB 702A

Phone: 996-5122

Department Affiliation(s)

Primary: School of Dentistry

Biographical Sketch
University of California at San Diego	BA	1978	Biochemistry
University of Southern California	PhD	1984	Craniofacial Biology
University of Southern California	Post-Doc	1984-85	Craniofacial Biology

	Society Memberships	Current Position	URL
1995-Present Ad Hoc Reviewer, National Institute for Dental and Craniofacial Research

Research/Clinical Interest Title

Research/Clinical Interest Description

Dr. Mary MacDougall is the Associate Dean for Research for the Dental School, Interim Chair of the Department of Pediatric Dentistry and Professor at the University of Texas Health Science Center at San Antonio Dental School. She earned her Ph.D. in Craniofacial Biology at the University of Southern California (USC) School of Dentistry and her B.A. in Biochemistry at the University of California at San Diego. She was the recipient of National Institute of Dental Research Fellowships during both her pre-doctoral and post-doctoral studies. In 1986, she joined the faculty at USC School of Dentistry as a Research Assistant Professor at the Center for Craniofacial Molecular Biology. In 1993, she joined the faculty at UTHSCSA, in 1998 she was promoted to Professor with tenure, and in 1999 became the Dental School’s first Associate Dean for Research. Dr. MacDougall’s research centers on the molecular mechanisms associated with tooth formation, tissue-specific cytodifferentation, extracellular matrix formation, tooth regeneration and related human genetic dental diseases. Her research in craniofacial genetics and biomimetics has been funded continuously since 1985. Currently, she is serving as President-Elect of the American Association for Dental Research (AADR) and director of a $5.5 million NIDCR program project grant investigating the molecular basis of tooth-specific gene regulation. In 2001, Dr. MacDougall received the International Association for Dental Research Distinguished Scientist Pulp Biology Research Award and in 2003, the National AADR Student Research Group Mentor of the Year Award. In 2000, Dr. MacDougall started the out reach program called “Dental Student Training in Academics and Research (DJSTAR)” an early intervention program targeting minority students to careers in dental academics. In 2002, she became the director of the dental schools training program “Craniofacial Oral-biology Student Training in Academic Research” (COJSTAR) funded by the NIDCR at just under $4.0 million dollars. Her research has been featured in several publications including Reader’s Digest and Men’s Health as well as several TV programs including Discovery Health Channel’s “The Painless Dentist”.

Postdoc Positions Available

N/A

Selected Publications 24

PubMed ID

Dong, J., Amore, D., Aldred, M., Gu, T.T., Escamilla, M., MacDougall, M. DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism Am. J. Medical Genetics (in press)

Chen, S. Santos, L., Wu, Y., Vuong, R., Gay, I., Schulze, J., Chuang H.H., MacDougall, M. Altered gene expression in human cleidocranial dysplasia dental pulp cells. Arch Oral Biol. (in press)

Dong, J., Gu, T.T., Jeffords, L., MacDougall, M. Dentin Phosphoprotein Compound Mutation in Dentin Sialophosphoprotein Causes Dentinogenesis Imperfecta Type III. Am. J. Medical Genetics (in press).

Teillaud, C., Nemere, I., Boukhobza, F., Mathiot, C., Conan, N., Oboeuf, M., Hotton, D., MacDougall, M., Berdal, A. Modulation of 1,25-dihydroxyvitatmin D3-membrane associated, rapid response steroid binding protein expression in mouse odontoblasts related to 1,25-(OH)2D3 . J Cell Biochem

Chen S, Unterbrink A, Kadaakkam S, Dong J, Gu TT, Dickson J, Chuang HH, MacDougall M. Regulation of the cell type-specific DSPP gene expression in mouse odontoblasts by a novel transcription repressor and an activator CBF. JCB: July 28, 2004.

Luo, W., Wen, X., Wang, H.J., MacDougall, M., Snead, M., Paine, M. In vivo overexpression of tuftelin in the enamel organic matrix. Cells tissues Organs, 2004 177:12-220.

Chen S, Inozentseva-Clyton N, Dong J, Gu TT, MacDougall M. Binding of two nuclear factors to a novel silencer element in hman dentin matrix protein 1 (DMP1) promoter regulates the cell type-specific DMP1 gene expression J Cell Biochem 15;92(2):332-249, 2004 .

Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y, Feng JQ.Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 279(18):19141-8, 2004.

MacDougall, M. Dental structural diseases mapping to human chromosome 4q21. Conn. Tissue Res. 44: 285-291,2003.

Sreenath, T., Thyagarajan, T., Hall, B., Longenecker, G., S’Souza, R., Hong, S., Wright, T., MacDougall, M., Sauk, J., Kulkarni. Dentin sialophosphoprotein knockout mouse display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta-III. JBC, Jul 4;278(27):24874-80, 2003.

Gluhak-Heinrich, J., Bonewald, L.F., Feng, J., MacDougall, M., Harris, S.E., Pavlin, D. Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. J Bone Min Res 18(5):807-817, 2003.

O’Sullivan M., MacDougall M., Unzeta M., Lizcano JM Tipton KF. Semicarbazide-sensitive amine oxidases in pig dental pulp. Biochim biophys Acta 1647 (1-2):333-336, 2003.

Papagerakis P, MacDougall M, Bailleul-Forestier I, Oboeuf M, Berdal A. Expression of amelogenin in odontoblasts. Bone 32(3):228-240, 2003.

MacDougall, M., Dong, J. Dentinogenesis Imperfecta Type III. The NORD Guide to Rare Disorders. Lippincott, Williams & Wilkins. Philadelphia, PA; 2003

Feng, J., Zhang, J., Dallas, S., Chen, S., Lu, Y., Owen, M., Harris, S., and MacDougall, M. Dentin Matrix protein 1 Gene is a target molecular of Cbfa1 in bone. J. Bone and Min. Res. 17(10):1822-1831,2002.

Papagerakis, P., Berdel, A., Mesbah, M., Peuchmaur, M., Malaval, L., Nydegger, J., Simmer, J. and MacDougall, M. Investigation of ostoeocalcin, osteonectin, and dentin sialophosphrotein in developing human teeth. Bone 30:377-385, 2002.

MacDougall, M., Simmons, D., Gu, T.T., and Dong, J. MEPE/OF45 a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. Conn. Tissue Res. 43:320-330,2002.

Unterbrink, A., O’Sullivan, M., Chen, S., MacDougall, M. TGF-1 downregulates DMP1 and DSPP in odontoblasts. Conn. Tissue Res. 43:345-358,2002.

Knight, C., Papagerakis, P., Simmons, D., Berdel, A., and MacDougall, M. Genomic organization and localization of mouse Nma/BAMBI: Posssible implications related to ameloblastoma formation. Conn. Tissue Res. 43:39-364,2002.

Papagerakis, P., MacDougall, M., and Berdal, A. Differential epithelial and mesechymal regulation of tooth-specific matrix protes expression by 1,25 dihydroxyvitamin D3 in vivo. Conn. Tissue Res. 43:372-375,2002.

Chen, S., Gu, T.T., Sreenath, T., Kulkarni, A.B., Karsenty, G., and MacDougall, M. Spatial expression of Cbfa1/Runx2 isoforms in teeth and characterization of binding sites in the DSPP gene. Conn. Tissue Res. 43:338-344,2002.

Lesot, F, Descroix, V, Mesbah, M, Hotton, D, Blin, C, Papagerakis, P, Mauro, N, Kato, S, MacDougall, M, Sharpe, P Berdal, A . Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralization. Connect Tissue Res 43:509-514,2002.

Berdal, A., Lezot, F, Pibouin, L, Hotton, D, Ghoul-Mazgar, S, Teillaud, C, Robert, B, MacDougall, M, Blin, C. C. Msx1 homeogene antisense mRNA in mouse dental and bone cells. Connect Tissue Res 43:148-152,2002.

MacDougall, M., Unterbrink, A., Carnes, D., Rani, S., Xianhong, L., Chen, S. Utilization of MO6-G3 Immortalized Odontoblast Cells in Studies Regarding Dentinogenesis. Adv Dental Res. 15:25-29, 2001.

Knight,C., Simmons,D., Gu, T.T., Gluhak-Heinrich,J., Pavlin,D., Zeichner-David, M., MacDougall, M. Cloning, characterization and tissue expression pattern of mouse Nma/BAMBI during odontogenesis. J Dental Res 80(10):1895-1902, 2001.

Blin-Wakkach, C., Lezot, F., Ghoul-Mazgar, S., Hotton, D., Monteiro, S., Teillaud, C., Pibouin, L., Orester-Cardoso, S., Papagerakis, P., MacDougall, M., Robert, B., and Berdal, A. Endogenous Msx1 antisense transcript:In vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammals. Proc Natl Acad Sci USA 98(13):7336-7341, 2001.

Karrman Mardh, C, Backman B, Golovleva, I, Simmons, D, Gu, TT, Holmgren , G, MacDougall, M, Forsman-Semb, K. (2001) Human ameloblastin gene: Genomic organization and mutational analysis in amelogenesis imperfecta patients. Eur J Oral Sci 109:8-13.

M.A. Torres-Quintana, S. Lécolle, D. Septier, B. Palmier, S. Rani, M. MacDougall, and M. Goldberg. Inositol Hexasulphate, a Casein Kinase Inhibitor Alters Enamel Formation in Cultured Embryonic Mouse Tooth Germs, JDent Res 79(10):1794-1801, 2000.

Dong, D., Gu, T.T., Simmons, D. MacDougall, M. Enamelin maps to human chromosome 4q21 within the

autosomal dominant amelogenesis imperfecta locus. Eur. J. Oral Sci. 108(5):353-358,2000.

MacDougall, M., Simmons, D., Gu, T.T., Forsman-Semb, K., Kärrman Mårdh, C., Mesbah,M., Forest, N., Krebsbach,PH, Yamada,Y and Berdal A. Cloning, characterization and immunolocalization of human ameloblastin. Eur. J. Oral Sci. 108(4):303-310, 2000.

MacDougall, M., Simmons, D., Gu, T.T., and Feng, J, Mouse DSPP Gene: Regulation and Evidence for a Single Gene. Amer Acad Ortho Surgery,317-322, 2000.

Feng, J., Luan, X., Li, X, Uterbrink, A., Harris, S and MacDougall, M. Dentin Matrix Protein 1 Gene: analysis of its Genomic Structure and Promoter Activity in Odontoblasts and Osteoblasts. Amer Acad Ortho Surgery, 155-159, 2000.

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Keywords

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Date Updated

09-15-05